Quantitative Detection of Ambroxol in Human Plasma Using HPLC-APCI-MS/MS: Application to a Pharmacokinetic Study
نویسندگان
چکیده
منابع مشابه
Quantitative Detection of Ambroxol in Human Plasma Using HPLC-APCI-MS/MS: Application to a Pharmacokinetic Study.
In this study, a rapid and reliable high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method for the determination of ambroxol in human plasma was developed and validated using palmatine as an internal standard (IS). Ambroxol and IS were extracted from 200 μL of human plasma via a simple protein precipitation preparation. Chromatographic separation was achieved on a P...
متن کاملDetermination of voriconazole in human plasma by HPLC-ESI-MS and application to pharmacokinetic study.
A fast, sensitive, high-performance liquid chromatography-tandem mass spectrometry method was developed for the determination of voriconazole in human plasma. Carbamazepine was used as the internal standard and the sample pretreatment involved one-step protein precipitation. Chromatographic separation was conducted on an Ultimate C18 column with a mobile phase consisting of acetonitrile-water (...
متن کاملDetermination of Acyclovir in Human Plasma Samples by HPLC Method with UV Detection: Application to Single-Dose Pharmacokinetic Study
BACKGROUND The aim of this study is estimation of pharmacokinetic parameters: Cmax, tmax, t1/2, AUC0-t and AUC0-∞ with the two-way analysis of variance, single observation (ANOVA) for two preparations containing acyclovir. OBJECTIVE In order to evaluate pharmacokinetic study of acyclovir, method for quantitative determination of acyclovir in human plasma should be simple, rapid and reproducib...
متن کاملDetermination of atenolol in human plasma by HPLC with fluorescence detection: validation and application in a pharmacokinetic study.
Atenolol is a cardioselective β1-adrenergic blocker widely used for the treatment of hypertension, angina pectoris and cardiac arrhythmias. A simple, specific, sensitive, precise and accurate high-performance liquid chromatography method with fluorescence detection has been developed and validated for the determination of atenolol in human plasma. After addition of the internal standard, the an...
متن کاملHPLC method for determination of atenolol in human plasma and application to a pharmacokinetic study in Turkey.
This paper describes a high-performance liquid chromatography method for the determination of atenolol in human plasma. Atenolol and the internal standard, metoprolol, were extracted from plasma by using a liquid-liquid extraction method. The method was developed on an Ace C18 reverse-phase column using a mobile phase of methanol-water (50:50, v/v) containing 0.1% trifluoroacetic acid. The cali...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Analytical Sciences
سال: 2017
ISSN: 0910-6340,1348-2246
DOI: 10.2116/analsci.33.1099